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KMID : 1033220130030010018
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Journal of Acute Care Surgery
2013 Volume.3 No. 1 p.18 ~ p.21
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Glucose Control in Sepsis
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Kim Sung-Jeep
Cho Hang-Joo
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Abstract
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Traditionally stress hyperglycemia was considered to be a adaptive response, with raised blood glucose providing a fuel for the brain, skeletal muscle, heart and other vital organs. In 2001, intensive insuline therapy (IIT) that demonstrated a survival benefit in surgical critical care led to clinicians to control glucose within tight range (＜110 mg/dl). However, randomized controlled studies including NICE-SUGAR study have shown IIT was no survival benefit compared with conventional therapy (CT). Now, controlling blood glucose within 140∼180 mg/dl in sepsis patients is accepted as reasonable range because IIT was related with frequent hypoglycemic events and no survival benefit compared with CT.
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KEYWORD
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Sepsis, Glucose control, ICU
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